RAF Typhoon FGR4s have conducted a mission with France's air force in a coordinated attack targeting an underground arms cache in Syrian territory operated by the IS group, per a report from the UK Ministry of Defence.
The site, located using surveillance, was thought to be containing munitions and bombs, the release indicated, and was located in mountainous terrain just above the historic site of Palmyra in the heart of Syria.
"Our fighter planes utilized precision-guided Paveway IV munitions to strike a series of entry passages providing entry to the site... early reports are that the target was engaged successfully," officials stated.
There was no evidence of any civilian impact in the strike conducted Saturday night and all the aircraft returned to base without incident, the defence officials confirmed.
The British jets were assisted by a Voyager aerial refuelling aircraft.
IS - referred to as the so-called Islamic State - enforced militant control over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This action demonstrates British leadership, and resolve to work closely with allied nations, to stamp out any revival of Daesh and their harmful and extremist ideologies in the Middle East," the British Defence Secretary John Healey said.
RAF aircraft have carried out surveillance missions over Syrian airspace to "forestall any efforts to regroup" of the group subsequent to its military defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I must thank the personnel of the UK armed forces involved in this strike for their expertise and their courage," Healey added. "They were among numerous British personnel on duty over the festive period. This operation, to eliminate dangerous terrorists who endanger our safety, demonstrates how British military are always on standby, throughout the year, protecting the UK within its borders and influential overseas."
During December, the United States armed forces conducted what it called a "massive strike" on IS targets in the country, after an ambush resulted in the deaths of two US servicemembers and a civilian interpreter in the Palmyra area.
The UN says IS still has roughly 5-7 thousand combatants in Syria and Iraq.